CHANGES IN THE ANTIOXIDANT SYSTEM AND HEMATOLOGICAL PARAMETERS DURING THE DEVELOPMENT OF OXIDATIVE STRESS IN HYPOTHYROIDISM.

Abstract

In our country, special attention is being paid to developing and implementing medications with positive effects for treating diseases associated with thyroid insufficiency. Thyroid diseases are the most widespread non-communicable endocrine disorders in the world, second only to diabetes in prevalence. Their occurrence depends on age, gender, and iodine consumption. A distinctive feature of hypothyroidism is the diversity and specificity of its clinical manifestations and symptoms. This makes diagnosing the disease challenging, potentially leading to misdiagnosis and subsequent iodine deficiency. There are three main types of hypothyroidism: primary, secondary, and peripheral. Primary hypothyroidism arises from damage to the thyroid gland itself. Secondary hypothyroidism develops as a result of damage to the pituitary gland (due to trauma, radiation, hemorrhage, or neuroinfection) and is significantly less prevalent than the primary form. Peripheral hypothyroidism is very rare and is caused by a disruption in tissue sensitivity to thyroid hormones. In this study, we are creating a model of hypothyroidism and investigating the changes in CAT, GGT, SOD, and MDA enzymes in the blood, as well as ALT and AST enzymes in the blood.