SYNTHESIS AND PROPERTIES OF ALLYL DERIVATIVES OF QUINAZOLIN-4-ONE
Referat
Yangi biologik faoliyatga ega bo‘lgan molekulalarni izlash jarayonida, xinazolin-4-onning allyl hosilalarini sintez qilish va ularning xususiyatlarini o‘rganish muhim ahamiyatga ega. Allyl va katalitik jarayonlar kabi organik sintez usullaridan foydalangan holda, ushbu tadqiqot uchun bir qator allyl bilan o‘zgartirilgan xinazolin-4-on hosilalari ishlab chiqildi. Allyl guruhlarining samarali qo‘shilganligini tekshirish maqsadida, ushbu hosilalarning tuzilmaviy xususiyatlari spektroskopik usullar, masalan, mass-spektrometriya, YaMR va IQ yordamida o‘rganildi. Yaratilgan birikmalar biologik faolligini baholaganda, farmatsevtika ishlab chiqarishda qo‘llash uchun umidverar natijalar ko‘rsatdi. Ular antibakterial va yallig‘lanishga qarshi faoliyat ko‘rsatdi. Bundan tashqari, ushbu birikmalarni turli sharoitlar ostida barqarorlik va kimyoviy reaktivliklari o‘rganildi, bu esa ularning sintetik moslashuvchanligi va funksional potentsialini aniqlashda foydali ma'lumotlar taqdim etdi. Natijalar xinazolin-4-on hosilalari bo‘yicha hozirgi tadqiqotlarga qo‘shimcha muhim ma'lumotlar kiritadi va ularning tibbiy kimyo sohasidagi mumkin bo‘lgan qo‘llanilishini ko‘rsatadi.
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