KETOROLAKNING MONOETANOLAMIN BILAN MOLEKULYAR KOMPLEKS BIRIKMASI SINTEZI VA STRUKTURAVIY TADQIQOTI
Referat
Bugungi kunda dunyo aholisi salomatligiga tevarak atrof muhitda sodir bo‘layotgan o‘zgarishlar kuchli ta’sir qilmoqda. Aholi sonining ortishi bilan tabiiyki, ularning oziq ovqat mahsulotlariga va dorivor vositalarga bo‘lgan ehtiyoji ortib bormoqda. Tabiatda sodir bo‘layotgan o‘zgarishlar tufayli barcha tirik organizmlarda turli-tuman kasalliklar tarqalishi va rivojlanishi kuchaygan. Bunday kasalliklarga saraton, gipertoniya, arterial gipertenziya, yurak ishemiyasi, nafas yo‘llari kasalliklari, turli darajadagi yallig‘lanish kasalliklari va boshqalar. Shu kabi kasalliklarni sonini ortishi bilan, tabiiyki ularni davolashda ishlatiladigan dorivor vositalarga bo‘lgan ehtiyoj ham kuchayadi. Kuchsiz yallig‘lanish kasallikllarni davolashda bir necha xil dorilar qo‘llaniladi. Masalan, ketorolak, ketoprofen, diklofenak, indometatsin va boshqalar. Bu maqolada nosteroid yallig‘lanishga qarshi keng qo‘llaniladigan dori vositasi hisoblangan ketorolakning monoetanolamin bilan molekulyar kompleks birikmasi sintezi va strukturaviy tadqiqoti amalga oshirildi. Ketorolakning o‘ziga nisbatan uning aralash ligandli koordinatsion birikmalari ta’sir doirasining ortishi ko‘plab tajriba ma’lumotlardan olingan ilmiy xulosalardan ma’lum. Bu o‘rinda ketorolaning aminospirt hisoblangan monoetanolamin bilan molekulyar kompleks birikmasi sintez qilinib, uning monokristallari o‘stirildi hamda unga tegishli parametrlar aniqlandi.
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