HIGH-PRESSURE INFLUENCE ON PIRACETAM CRYSTALS: STUDYING BY QUANTUM CHEMICAL METHODS
Referat
In this study, we aim at developing a robust crystallization process for the ionic cocrystal between piracetam and CaCl2. We discuss the structural characteristics of the piracetam-CaCl2 cocrystal and its thermal behavior, furthermore we develop a robust crystallization process by construction of appropriate phase diagrams. CaCl2 and piracetam form an ionic dihydrate cocrystal with formula piracetam•CaCl2 •H2O, in which the Ca2+ cation adopts an octahedral coordination with the oxygens of 4 different molecules of piracetam and of two water molecules. According to the TGA, DSC and VT-XRPD, the cocrystal exhibits improved thermal stability compared to the parent drug compound. In this article we show how one can develop a robust, water-based cocrystallization process for ionic cocrystals, a relatively underexplored part of the cocrystal landscape. We also discuss the common ion effect on cocrystallization, and show how acommon ion can strongly impact on the solubility of the cocrystal, as well as its constituting components. In addition, acommon ion will also strongly impact the size of the cocrystal region in the ternary phase diagram.
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