VINKA TURKUMIGA MANSUB OʻSIMLIKLARDAN AJRATILGAN ENDOFIT ZAMBURUGʻLARDAN VINKA ALKOLOIDLARINI ISHLAB CHIQARISH DINAMIKASI

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Referat

Maqolada Vinca turkumidagi o'simliklardan avval ajratilgan endofit zamburug'lardan vinka alkaloidlari ishlab chiqarish dinamikasi tahlili keltirilgan. Tadqiqotning maqsadi makkajo'xori suyuq  ozuqa muhitida, zamburug’larning  7, 10 va 13 sutka davomida o'sish jarayonidagi, vinkristin, vinblastin va vinkamin alkaloidlarini YSSX usuli yordamida aniqlash edi. Natijalar shuni ko'rsatdiki, makkajo'xori suyuq ozuqa muhitda biomassaning maksimal to'planishi zamburug’ shtammlarni o’sishining  7-kunida kuzatildi, alkaloid ishlab chiqarish esa o'sishga aniq bog'liq emas va shtammning o'ziga xos xususiyatlari bilan belgilanadi.

Adabiyotlar ro'yxati

References Singh, R., Dubey, A., 2015. Endophytic actinomycetes as emerging source for therapeutic compounds. Indo Glob. J. Phram. Sci. 5 (2), 106–116.

Newman, D.J., Cragg, G.M., 2020. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 83 (3), 770–803 Dudeja, S.S., Giri, R., 2014. Beneficial properties, colonization, establishment and molecular diversity of endophytic bacteria in legumes and non legumes. Afr. J. Microbiol. Res. 8 (15), 1562–1572.

Chandra, S., 2012. Endophytic fungi: novel sources of anticancer lead molecules. Appl. Microbiol. Biotechnol. 95 (1), 47–59.

Dudeja, S.S., Giri, R., 2014. Beneficial properties, colonization, establishment and molecular diversity of endophytic bacteria in legumes and non legumes. Afr. J. Microbiol. Res. 8 (15), 1562–1572.

Namdar, D., Charuvi, D., Ajjampura, V., Mazuz, M., Ion, A., Kamara, I., Koltai, H., 2019. LED lighting affects the composition and biological activity of Cannabis sativa secondary metabolites. Ind. Crop. Prod. 132, 177–185.

Albuquerque, B.R., Heleno, S.A., Oliveira, M.B.P., Barros, L., Ferreira, I.C., 2021. Phenolic compounds: current industrial applications, limitations and future challenges. Food Funct. 12 (1), 14–29.

Bryda, O., Stadnytska, N., 2021. Extraction methods of extractive substances from medicinal plant raw materials: advantages and limitations. Ann. Rom. Soc. Cell Biol. 25 (5), 1737–1751. 〈http://annalsofrscb.ro/index.php/journal/article/view/4697〉.

Khare E., Mishra J., Arora NK Multifaceted Interactions Between Endophytes and Plant: Developments and Prospects.Old. Mikrobiol. 2018;9:2732. Doi: 10.3389/fmicb.2018.02732. [ DOI ] [ PMC bepul maqola ] [ PubMed ] [ Google Scholar

Fadiji A.E., Babalola O.O. Elucidating mechanisms of endophytes used in plant protection and other bioactivities with multifunctional prospects. Front. Bioeng. Biotechnol. 2020;8:467. Doi: 10.3389/fbioe.2020.00467. [DOI] [PMC free article] [PubMed] [Google Scholar]

Pham H.N.T., Vuong Q.V., Bowyer M.C., Scarlett C.J. Phytochemicals derived from Catharanthus roseus and their health benefits. Technologies. 2020;8:80. Doi: 10.3390/technologies8040080. [DOI] [Google Scholar]

Tiwari P., Nithya R., Mahalingam G. Antidiabetic activity of endophytic fungi isolated from Ficus religiosa. Asian J. Pharm. Clin. Res. 2017;10:59. Doi: 10.22159/ajpcr.2017.v10i4.14718. [DOI] [Google Scholar].

Pandey S.S., Singh S., Babu C.S.V., Shanker K., Srivastava N.K., Shukla A.K., Kalra A. Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis. Sci. Rep. 2016;6:26583. Doi: 10.1038/srep26583. [DOI] [PMC free article] [PubMed] [Google Scholar]

Suddhasuchi Das and Amit B Sharangi, Madagascar periwinkle (Catharanthus roseus L.): Diverse medicinal and therapeutic benefits to humankind. Journal of Pharmacognosy and Phytochemistry 2017; 6(5): 1695-1701 2017

J.N.Mishra, N. K. Verma. A brief study on Catharanthus Roseus: A review International Journal of Research in Pharmacy and Pharmaceutical Sciences. March 2017; Page No. 20-23

Emanuela Martinoa , Giuseppe Casamassimab , Sonia Castiglioneb , Edoardo Cellupicab , Serena Pantaloneb , Francesca Papagnib , Marta Ruib , Angela Marika Sicilianob , Simona Colli.nab, Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead. Bioorganic & Medicinal Chemistry LettersVolume 28, Issue 17, 15 September 2018, Pages 2816-2826

Ashoka H, Hegde P, Madihalli C et al (2017) Isolation and detection of vinca alkaloids from endophytes isolated from Catharanthus roseus. Eur J Biomed Pharm Sci 10:675–683

Kumar A, Patil D, Rajamohanan PR, Ahmad A (2013) Isolation, Purification and Characterization of Vinblastine and Vincristine from Endophytic Fungus Fusarium oxysporum Isolated from Catharanthus roseus. PLoS ONE 8(9): e71805. doi:10.1371/journal.pone.0071805. September 2013 | Volume 8 | Issue 9 | e7180

R.Parthasarathy a, R.Shanmuganathan b, A.Pugazhendhi c Vinblastine production by the endophytic fungus Curvularia verruculosa from the leaves of Catharanthus roseus and its in vitro cytotoxicity against HeLa cell line. Analytical Biochemistry. Volume 593, 15 March 2020, 113530. https://doi.org/10.1016/j.ab.2019.113530.]

Qanday qilib iqtibos keltirish mumkin

Otayeva Murotovna, Nasmetova Mamajanovna, Gulyamova Gafurovna , Z. S. T. (2025). VINKA TURKUMIGA MANSUB OʻSIMLIKLARDAN AJRATILGAN ENDOFIT ZAMBURUGʻLARDAN VINKA ALKOLOIDLARINI ISHLAB CHIQARISH DINAMIKASI. Qo‘qon DPI. Ilmiy Xabarlar Jurnali, 5(2). Retrieved from https://ilmiyxabarlar.kspi.uz/index.php/journal/article/view/1307
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